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Article

Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2.

Scientific reports - 5 May 2016

San Bilge, Chrispijn Naomi D, Wittkopp Nadine, van Heeringen Simon J, Lagendijk Anne K, Aben Marco, Bakkers Jeroen, Ketting René F, Kamminga Leonie M

Abstract excerpt

Polycomb group (PcG) proteins are transcriptional repressors of numerous genes, many of which regulate cell cycle progression or developmental processes. We used zebrafish to study Enhancer of zeste homolog 2 (Ezh2), the PcG protein responsible for placing the transcriptional repressive H3K27me3 mark. We identified a nonsense mutant of ezh2 and generated maternal zygotic (MZ) ezh2 mutant embryos. In contrast to...

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Identifiers

PMID: 27145952
DOI: 10.1038/srep24658
PMCID: PMC4857124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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