Article
Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.
Development (Cambridge, England) - 1 Jan 2005
McDermott Aileen, Gustafsson Marcus, Elsam Thomas, Hui Chi-Chung, Emerson Charles P, Borycki Anne-Gaëlle
Abstract excerpt
The Gli family of zinc finger transcription factors are mediators of Shh signalling in vertebrates. In previous studies, we showed that Shh signalling, via an essential Gli-binding site in the Myf5 epaxial somite (ES) enhancer, is required for the specification of epaxial muscle progenitor cells. Shh signalling is also required for the normal mediolateral patterning of myogenic cells within the somite. In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
