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Article

A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Mar 2007

Wang Chengbing, Pan Yong, Wang Baolin

Abstract excerpt

Gli3 protein processing to generate the Gli3 repressor is mediated by proteasome and inhibited by Hedgehog signaling. The Gli3 repressor concentration is graded along the anterior-posterior axis of the developing vertebrate limb due to posteriorly restricted Sonic hedgehog expression. In this study, we created a small deletion at the Gli3 locus (Gli3(Delta68)), which causes a half reduction in the Gli3 repressor...

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PMID: 17266131
DOI: 10.1002/dvdy.21082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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