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Article

Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development.

Mechanisms of development - 1 Mar 1997

Büscher D, Bosse B, Heymer J, Rüther U

Abstract excerpt

Sonic hedgehog (Shh) expression in the developing limb is associated with the zone of polarising activity (ZPA), and both are restricted to the posterior part of the limb bud. We show that the expression patterns of Shh and Gli3, a member of the Gli-family believed to function in transcriptional control, appear to be mutually exclusive in limb buds of mouse embryos. In the polydactyly mouse mutant extra toes...

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Identifiers

PMID: 9152009
DOI: 10.1016/s0925-4773(97)00656-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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