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Article

The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.

Developmental biology - 15 May 2007

Wang Chengbing, Rüther Ulrich, Wang Baolin

Abstract excerpt

Anterior-posterior (A/P) limb patterning in vertebrates is determined by the counteraction between the Sonic Hedgehog (Shh) and the Gli3 transcription factor. Shh exerts its effect on Gli3 by regulating the full-length Gli3 protein processing to generate a Gli3 repressor gradient along the A/P axis of the limb. However, it is not clear whether the full-length Gli3 is an activator in vivo and plays any role in the...

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Identifiers

PMID: 17400206
DOI: 10.1016/j.ydbio.2007.02.029
PMCID: PMC1952533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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