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Article

Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.

Human molecular genetics - 15 Apr 2012

Quinn Malgorzata E, Haaning Allison, Ware Stephanie M

Abstract excerpt

Limb anomalies are important birth defects that are incompletely understood genetically and mechanistically. GLI3, a mediator of hedgehog signaling, is a genetic cause of limb malformations including pre- and postaxial polydactyly, Pallister-Hall syndrome and Greig cephalopolysyndactyly. A closely related Gli (glioma-associated oncogene homolog)-superfamily member, ZIC3, causes X-linked heterotaxy syndrome in...

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Source

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Identifiers

PMID: 22234993
DOI: 10.1093/hmg/dds002
PMCID: PMC3313802

Genes

GLI3
ZIC3

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.PMID 22234993Read ↗

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