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Article

Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.

Developmental biology - 15 Jul 2013

Cao Ting, Wang Chengbing, Yang Mei, Wu Chuanqing, Wang Baolin

Abstract excerpt

Anterioposterior vertebrate limb patterning is controlled by opposing action between Sonic Hedgehog (Shh) and the Gli3 transcriptional repressor. Unexpectedly, Gli3(Δ699) mutant mice, which are thought to express only a Gli3 repressor and not the full-length activator, exhibit limb phenotypes inconsistent with those of Shh mutant mice. Therefore, it remains debatable whether Shh patterns the anterioposterior limb...

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Identifiers

PMID: 23644062
DOI: 10.1016/j.ydbio.2013.04.025
PMCID: PMC3707282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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