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Article

Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.

Science (New York, N.Y.) - 25 Oct 2002

te Welscher Pascal, Zuniga Aimée, Kuijper Sanne, Drenth Thijs, Goedemans Hans J, Meijlink Frits, Zeller Rolf

Abstract excerpt

Distal limb development and specification of digit identities in tetrapods are under the control of a mesenchymal organizer called the polarizing region. Sonic Hedgehog (SHH) is the morphogenetic signal produced by the polarizing region in the posterior limb bud. Ectopic anterior SHH signaling induces digit duplications and has been suspected as a major cause underlying congenital malformations that result in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12215652
DOI: 10.1126/science.1075620

Genes

SHH
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Progression of vertebrate limb development through SHH-mediated counteraction of GLI3.PMID 12215652Read ↗

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The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning.Semantic proximity Read ↗

Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants.Semantic proximity Read ↗

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.Semantic proximity Read ↗

The disruption of a novel limb cis-regulatory element of SHH is associated with autosomal dominant preaxial polydactyly-hypertrichosis.Semantic proximity Read ↗

Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice.Semantic proximity Read ↗

Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds.Semantic proximity Read ↗

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Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning.Semantic proximity Read ↗

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