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Article

Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.

PLoS genetics - 8 Apr 2010

Galli Antonella, Robay Dimitri, Osterwalder Marco, Bao Xiaozhong, Bénazet Jean-Denis, Tariq Muhammad, Paro Renato, Mackem Susan, Zeller Rolf

Abstract excerpt

The polarization of nascent embryonic fields and the endowment of cells with organizer properties are key to initiation of vertebrate organogenesis. One such event is antero-posterior (AP) polarization of early limb buds and activation of morphogenetic Sonic Hedgehog (SHH) signaling in the posterior mesenchyme, which in turn promotes outgrowth and specifies the pentadactylous autopod. Inactivation of the Hand2...

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Source

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Identifiers

PMID: 20386744
DOI: 10.1371/journal.pgen.1000901
PMCID: PMC2851570

Genes

SHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.PMID 20386744Read ↗

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