Article
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.
Genome medicine - 8 Oct 2015
Voisin Sarah, Almén Markus Sällman, Zheleznyakova Galina Y, Lundberg Lina, Zarei Sanaz, Castillo Sandra, Eriksson Fia Ence, Nilsson Emil K, Blüher Matthias, Böttcher Yvonne, Kovacs Peter, Klovins Janis, Rask-Andersen Mathias, Schiöth Helgi B
Abstract excerpt
BACKGROUND: The mechanisms by which genetic variants, such as single nucleotide polymorphisms (SNPs), identified in genome-wide association studies act to influence body mass remain unknown for most of these SNPs, which continue to puzzle the scientific community. Recent evidence points to the epigenetic and chromatin states of the genome as having important roles. METHODS: We genotyped 355 healthy young...
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