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Article

Comprehensive characterization genetic regulation and chromatin landscape of enhancer-associated long non-coding RNAs and their implication in human cancer.

Briefings in bioinformatics - 17 Jan 2022

Li Xin, Pan Xu, Zhou Hanxiao, Wang Peng, Gao Yue, Shang Shipeng, Guo Shuang, Sun Jie, Xiong Zhiying, Ning Shangwei, Zhi Hui, Li Xia

Abstract excerpt

Long non-coding RNAs (lncRNAs) that emanate from enhancer regions (defined as enhancer-associated lncRNAs, or elncRNAs) are emerging as critical regulators in disease progression. However, their biological characteristics and clinical relevance have not been fully portrayed. Here, based on the traditional expression quantitative loci (eQTL) and our optimized residual eQTL method, we comprehensively described the...

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PMID: 34581409
DOI: 10.1093/bib/bbab401

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