Article

Pan-cancer characterization and clinical outcome of ecDNA-enhancer mediated transcriptional dysregulation

2023-09-10

Abstract excerpt

Extrachromosomal circular DNAs (ecDNAs) are extrachromosomal circular DNA elements harboring enhancers that can function as mobile transcriptional enhancers to promote oncogene amplification in diverse human cancers. However, little is known about the mechanism how ecDNA and relevant enhancers influence the transcription control in different cancers. Here, we performed a comprehensive pan-cancer analysis to explor...

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Literature Corpus work: 32a9e4b5-98d3-5689-8dc0-34760a6bc4da
DOI: 10.1101/2023.09.06.556610

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