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Article

Leveraging Tissue-Specific Enhancer-Target Gene Regulatory Networks Identifies Enhancer Somatic Mutations That Functionally Impact Lung Cancer.

Cancer research - 2 Jan 2024

Hariprakash Judith Mary, Salviato Elisa, La Mastra Federica, Sebestyén Endre, Tagliaferri Ilario, Silva Raquel Sofia, Lucini Federica, Farina Lorenzo, Cinquanta Mario, Rancati Ilaria, Riboni Mirko, Minardi Simone Paolo, Roz Luca, Gorini Francesca, Lanzuolo Chiara, Casola Stefano, Ferrari Francesco

Abstract excerpt

Enhancers are noncoding regulatory DNA regions that modulate the transcription of target genes, often over large distances along with the genomic sequence. Enhancer alterations have been associated with various pathological conditions, including cancer. However, the identification and characterization of somatic mutations in noncoding regulatory regions with a functional effect on tumorigenesis and prognosis...

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Source

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Identifiers

PMID: 37855660
DOI: 10.1158/0008-5472.CAN-23-1129
PMCID: PMC10758689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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