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Article

AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes.

Bioinformatics (Oxford, England) - 15 Jul 2018

Lee Wanseon, Plant Katharine, Humburg Peter, Knight Julian C

Abstract excerpt

Motivation: Reliance on mapping to a single reference haplotype currently limits accurate estimation of allele or haplotype-specific expression using RNA-sequencing, notably in highly polymorphic regions such as the major histocompatibility complex. Results: We present AltHapAlignR, a method incorporating alternate reference haplotypes to generate gene- and haplotype-level estimates of transcript abundance for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29514179
DOI: 10.1093/bioinformatics/bty125
PMCID: PMC6041798

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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