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Article

Prediction of HLA genotypes from single-cell transcriptome data.

Frontiers in immunology - 1 Jan 2023

Solomon Benjamin D, Zheng Hong, Dillon Laura W, Goldman Jason D, Hourigan Christopher S, Heath James R, Khatri Purvesh

Abstract excerpt

The human leukocyte antigen (HLA) locus plays a central role in adaptive immune function and has significant clinical implications for tissue transplant compatibility and allelic disease associations. Studies using bulk-cell RNA sequencing have demonstrated that HLA transcription may be regulated in an allele-specific manner and single-cell RNA sequencing (scRNA-seq) has the potential to better characterize these...

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Identifiers

PMID: 37180102
DOI: 10.3389/fimmu.2023.1146826
PMCID: PMC10167300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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