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A compendium of methods: Searching allele specific expression via RNA sequencing.

Gene - 5 Feb 2025

Niharika, Asthana Shailendra, Narayan Yadav Harlokesh, Sharma Nanaocha, Kumar Singh Vijay

Abstract excerpt

Diploid mammalian genome has paired alleles for each gene; typically allowing for equal expression of the two alleles within the cell/tissue. However, genetic regulatory elements and epigenetic modifications can disrupt this equality, leading to preferential expression of one allele. Examining high-confidence allele-specific expression (ASE) is vital for understanding genetic variations and their impact on major...

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PMID: 39561903
DOI: 10.1016/j.gene.2024.149102

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