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Article

scHLAcount: allele-specific HLA expression from single-cell gene expression data.

Bioinformatics (Oxford, England) - 1 Jun 2020

Darby Charlotte A, Stubbington Michael J T, Marks Patrick J, Martínez Barrio Álvaro, Fiddes Ian T

Abstract excerpt

SUMMARY: Bulk RNA sequencing studies have demonstrated that human leukocyte antigen (HLA) genes may be expressed in a cell type-specific and allele-specific fashion. Single-cell gene expression assays have the potential to further resolve these expression patterns, but currently available methods do not perform allele-specific quantification at the molecule level. Here, we present scHLAcount, a post-processing...

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PMID: 32330223
DOI: 10.1093/bioinformatics/btaa264
PMCID: PMC7320622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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