Article

Complete sequences of six Major Histocompatibility Complex haplotypes, including all the major <i>MHC class II</i> structures

2022-04-29

Abstract excerpt

Accurate and comprehensive immunogenetic reference panels are key to the successful implementation of population-scale immunogenomics. The 5Mbp Major Histocompatibility Complex (MHC) is the most polymorphic region of the human genome and associated with multiple immune-mediated diseases, transplant matching and therapy responses. Analysis of MHC genetic variation is severely complicated by complex patterns of sequ...

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Literature Corpus work: 0c1ea337-f79c-5683-a661-15e69c66b96b
DOI: 10.1101/2022.04.28.489875

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