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Article

ARID1A loss in cancer: Towards a mechanistic understanding.

Pharmacology & therapeutics - 1 Oct 2018

Mathur Radhika

Abstract excerpt

Genes encoding subunits of SWI/SNF chromatin remodeling complexes are collectively mutated in 20% of all human cancers. ARID1A is the SWI/SNF subunit gene that is most frequently mutated, at variable frequencies across molecular and histological subtypes of cancer. Mouse modeling has revealed that the role of ARID1A in tumor suppression is highly dependent upon context. Recent mechanistic studies have identified...

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Identifiers

PMID: 29730444
DOI: 10.1016/j.pharmthera.2018.05.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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