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Article

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.

Molecular and cellular biology - 1 Mar 2014

Wilson Boris G, Helming Katherine C, Wang Xiaofeng, Kim Youngha, Vazquez Francisca, Jagani Zainab, Hahn William C, Roberts Charles W M

Abstract excerpt

Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of the most frequently mutated. The SWI/SNF complex modulates chromatin remodeling through the activity of two mutually exclusive catalytic subunits, SMARCA4 and SMARCA2 (BRM). Here, we show that a SMARCA2-containing residual SWI/SNF complex...

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Identifiers

PMID: 24421395
DOI: 10.1128/MCB.01372-13
PMCID: PMC3958034

Genes

SMARCA2
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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