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Article

The SWI/SNF Complex: A Frequently Mutated Chromatin Remodeling Complex in Cancer.

Cancer treatment and research - 1 Jan 2023

Nguyen Vinh The, Tessema Mathewos, Weissman Bernard Ellis

Abstract excerpt

The switch/sucrose non-fermenting (SWI/SNF) chromatin remodeling complex is a global regulator of gene expression known to maintain nucleosome-depleted regions at active enhancers and promoters. The mammalian SWI/SNF protein subunits are encoded by 29 genes and 11-15 subunits including an ATPase domain of either SMARCA4 (BRG1) or SMARCA2 (BRM) are assembled into a complex. Based on the distinct subunits, SWI/SNF...

Topics

Animals
Humans
Chromatin Assembly and Disassembly
Neoplasms
Mutation
Chromatin
Mammals
DNA Helicases
Nuclear Proteins
Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38113003
DOI: 10.1007/978-3-031-45654-1_7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38113003-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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