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Article

Increased insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 May 2018

Tura Andrea, Bizzotto Roberto, Yamada Yuchiro, Seino Yutaka, Pacini Giovanni, Ahrén Bo

Abstract excerpt

To establish whether incretin hormones affect insulin clearance, the aim of this study was to assess insulin clearance in mice with genetic deletion of receptors for both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), so called double incretin receptor knockout mice (DIRKO). DIRKO ( n = 31) and wild-type (WT) C57BL6J mice ( n = 45) were intravenously injected with...

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Source

Identifiers

PMID: 29351421
DOI: 10.1152/ajpregu.00181.2017

Genes

GIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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