Article
K(ATP) channel knockout mice crossbred with transgenic mice expressing a dominant-negative form of human insulin receptor have glucose intolerance but not diabetes.
Endocrine journal - 1 Apr 2004
Kanezaki Yoshiko, Obata Toshiyuki, Matsushima Rie, Minami Asako, Yuasa Tomoyuki, Kishi Kazuhiro, Bando Yoshimi, Uehara Hisanori, Izumi Keisuke, Mitani Tasuku, Matsumoto Mitsuru, Takeshita Yukari, Nakaya Yutaka, Matsumoto Toshio, Ebina Yousuke
Abstract excerpt
Impaired insulin secretion and insulin resistance are thought to be two major causes of type 2 diabetes mellitus. There are two kinds of diabetic model mice: one is a K(ATP) channel knockout (Kir6.2KO) mouse which is defective in glucose-induced insulin secretion, and the other is a transgenic mouse expressing the tyrosine kinase-deficient (dominant-negative form of) human insulin receptor (hIR(KM)TG), and which...
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