Article
Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.
Regulatory peptides - 15 Feb 2005
Herbach Nadja, Goeke Burkhard, Schneider Marlon, Hermanns Walter, Wolf Eckhard, Wanke Ruediger
Abstract excerpt
The expression of a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) under the control of the rat pro-insulin gene promoter induces severe diabetes mellitus in transgenic mice. This study aims to gain further insight into the effect of the expression of a dominant negative GIPR on glucose homeostasis and postnatal development of the endocrine pancreas. The diabetic phenotype of...
Topics
- Animals
- Animals, Newborn
- Area Under Curve
- Blood Glucose
- Body Weight
- DNA
- DNA, Complementary
- Female
- Genes, Dominant
- Glucagon
- Glucagon-Like Peptide 1
- Glucose
- Glucose Tolerance Test
- Immunohistochemistry