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Article

Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.

Regulatory peptides - 15 Feb 2005

Herbach Nadja, Goeke Burkhard, Schneider Marlon, Hermanns Walter, Wolf Eckhard, Wanke Ruediger

Abstract excerpt

The expression of a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn) under the control of the rat pro-insulin gene promoter induces severe diabetes mellitus in transgenic mice. This study aims to gain further insight into the effect of the expression of a dominant negative GIPR on glucose homeostasis and postnatal development of the endocrine pancreas. The diabetic phenotype of...

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Source

Identifiers

PMID: 15582721
DOI: 10.1016/j.regpep.2004.08.021

Genes

GIP
GIPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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