Article

A high-resolution mass spectrometry-based method for quantifying insulin-stimulated glucose uptake in mice following an intraperitoneal injection of tracer

2026-04-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> A catheter-free, non-radiolabeled method that permits in vivo measurement of tissue-specific glucose uptake does not exist. To address this gap, we sought to develop and validate a new, higher throughput mass spectrometry (MS)-based method that combines an injection of insulin with a non-radiolabeled glucose tracer, 2-fluoro-2-deoxyglucose (2FDG), to determine insulin-stimul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e98d2063-592e-5c4f-a0bc-850efdb94a6e
DOI: 10.64898/2026.03.31.714892

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A high-resolution mass spectrometry-based method for quantifying insulin-stimulated glucose uptake in mice following an intraperitoneal injection of tracerDOI 10.64898/2026.03.31.714892Read

Approach to assessing determinants of glucose homeostasis in the conscious mouse.Semantic proximity Read

Increased insulin clearance in mice with double deletion of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptors.Semantic proximity Read

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.Semantic proximity Read

MKR mice have increased dynamic glucose disposal despite metabolic inflexibility, and hepatic and peripheral insulin insensitivity.Semantic proximity Read

A review of standardized metabolic phenotyping of animal models.Semantic proximity Read

Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models.Semantic proximity Read

Tracing metabolic flux in vivo: basic model structures of tracer methodologySemantic proximity Read

A Precision Medicine Approach to Metabolic Therapy for Breast Cancer in MiceSemantic proximity Read

Glucose clearance and uptake is increased in the SOD1 <sub>G93A</sub> mouse model of amyotrophic lateral sclerosis through an insulin-independent mechanismSemantic proximity Read

Pre-exposure to time-restricted feeding reduces tissue CD4 <sup>+</sup> T cells with a limited effect on <i>Mycobacterium tuberculosis</i> clearance at the early time pointSemantic proximity Read

How to measure insulin sensitivity.Semantic proximity Read

RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese miceSemantic proximity Read