Article
Quantitative Proteomics of Intestinal Mucosa From Male Mice Lacking Intestinal Epithelial Insulin Receptors.
Endocrinology - 1 Aug 2017
Jensen Stina Rikke, Schoof Erwin M, Wheeler Sarah E, Hvid Henning, Ahnfelt-Rønne Jonas, Hansen Bo Falck, Nishimura Erica, Olsen Grith Skytte, Kislinger Thomas, Brubaker Patricia L
Abstract excerpt
The goal of the present study was to determine whether loss of the insulin receptor alters the molecular landscape of the intestinal mucosa, using intestinal-epithelial insulin receptor knockout (IE-irKO) mice and both genetic (IRfl/fl and Villin-cre) controls. Quantitative proteomic analysis by liquid chromatography mass spectrometry was applied to jejunal and colonic mucosa from mice fed a normal chow diet and...
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