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Article

Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of Diabetes

1 Jan 2003

Abstract excerpt

A central component of type 2 diabetes and the metabolic syndrome is insulin resistance. Insulin exerts a multifaceted and highly integrated series of actions via its intracellular signaling systems. Generation of mice carrying null mutations of the genes encoding proteins in the insulin signaling pathway provides a unique approach to determining the role of individual proteins in the molecular mechanism of...

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Identifiers

PMID: 15061645
DOI: 10.1155/edr.2003.169

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