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Knockout mouse models of insulin signaling: Relevance past and future

1 Jan 2014

Abstract excerpt

Insulin resistance is a hallmark of type 2 diabetes. In an effort to understand and treat this condition, researchers have used genetic manipulation of mice to uncover insulin signaling pathways and determine the effects of their perturbation. After decades of research, much has been learned, but the pathophysiology of insulin resistance in human diabetes remains controversial, and treating insulin resistance...

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PMID: 24748928
DOI: 10.4239/wjd.v5.i2.146

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