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Article

Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance.

PloS one - 1 Jan 2011

Abdul-Hay Samer O, Kang Dongcheul, McBride Melinda, Li Lilin, Zhao Ji, Leissring Malcolm A

Abstract excerpt

BACKGROUND: Insulin-degrading enzyme (IDE) is widely recognized as the principal protease responsible for the clearance and inactivation of insulin, but its role in glycemic control in vivo is poorly understood. We present here the first longitudinal characterization, to our knowledge, of glucose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21695259
DOI: 10.1371/journal.pone.0020818
PMCID: PMC3111440

Genes

IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21695259-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance.PMID 21695259Read ↗

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