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Article

Atomistic Insights into Structural Differences between E3 and E4 Isoforms of Apolipoprotein E.

Biophysical journal - 19 Dec 2017

Ray Angana, Ahalawat Navjeet, Mondal Jagannath

Abstract excerpt

Among various isoforms of Apolipoprotein E (ApoE), the E4 isoform (ApoE4) is considered to be the strongest risk factor for Alzheimer's disease, whereas the E3 isoform (ApoE3) is neutral to the disease. Interestingly, the sequence of ApoE4 differs from its wild-type ApoE3 by a single amino acid C112R in the 299-amino-acid-long sequence. Hence, the puzzle remains: how a single-amino-acid difference between the...

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Identifiers

PMID: 29262361
DOI: 10.1016/j.bpj.2017.10.006
PMCID: PMC5770556

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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