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Article

Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4.

The Journal of biological chemistry - 15 Jul 2005

Hatters Danny M, Peters-Libeu Clare A, Weisgraber Karl H

Abstract excerpt

Apolipoprotein (apo) E4 is a major risk factor for Alzheimer and cardiovascular diseases. ApoE4 differs from the two other common isoforms (apoE2 and apoE3) by its lower resistance to denaturation and greater propensity to form partially folded intermediates. As a first step to determine the importance of stability differences in vivo, we reengineered a partially humanized variant of the amino-terminal domain of...

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Identifiers

PMID: 15890642
DOI: 10.1074/jbc.M503910200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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