Article

Apolipoprotein E4 has extensive conformational heterogeneity in lipid free and bound forms

2022-02-04

Abstract excerpt

The ε4-allele variant of Apolipoprotein E (ApoE4) is the strongest genetic risk factor for Alzheimer’s disease, though it only differs from its neutral counterpart ApoE3 by a single amino acid substitution. While ApoE4 influences the formation of plaques and neurofibrillary tangles, the structural determinants of pathogenicity remain undetermined due to limited structural information. We apply a combination of sin...

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Literature Corpus work: c108818a-0cf6-54ff-b7dd-2a665f166e0d
DOI: 10.1101/2022.02.02.478828

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