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Article

Helical structure, stability, and dynamics in human apolipoprotein E3 and E4 by hydrogen exchange and mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2017

Chetty Palaniappan S, Mayne Leland, Lund-Katz Sissel, Englander S Walter, Phillips Michael C

Abstract excerpt

Apolipoprotein E (apoE) plays a critical role in cholesterol transport in both peripheral circulation and brain. Human apoE is a polymorphic 299-residue protein in which the less common E4 isoform differs from the major E3 isoform only by a C112R substitution. ApoE4 interacts with lipoprotein particles and with the amyloid-β peptide, and it is associated with increased incidence of cardiovascular and Alzheimer's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28096372
DOI: 10.1073/pnas.1617523114
PMCID: PMC5293021

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