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Article

Concerning the structure of apoE.

Protein science : a publication of the Protein Society - 1 Dec 2013

Frieden Carl, Garai Kanchan

Abstract excerpt

Apolipoprotein E (apoE), first described in 1973, is a truly fascinating protein. While studies initially focused on its role in cholesterol and lipid metabolism, one apoE isoform (apoE4) is a major risk factor for development of late onset Alzheimer's disease. Yet the difference between apoE3, the common form, and apoE4 is a single amino acid of the 299 in this 34 kDa protein. Structure determination of the two...

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Identifiers

PMID: 24115173
DOI: 10.1002/pro.2379
PMCID: PMC3843636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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