Article
Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.
Molecular neurodegeneration - 6 Jun 2023
Nemergut Michal, Marques Sérgio M, Uhrik Lukas, Vanova Tereza, Nezvedova Marketa, Gadara Darshak Chandulal, Jha Durga, Tulis Jan, Novakova Veronika, Planas-Iglesias Joan, Kunka Antonin, Legrand Anthony, Hribkova Hana, Pospisilova Veronika, Sedmik Jiri, Raska Jan, Prokop Zbynek, Damborsky Jiri, Bohaciakova Dasa, Spacil Zdenek, Hernychova Lenka, Bednar David, Marek Martin
Abstract excerpt
BACKGROUND: Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor for late-onset Alzheimer's Disease (AD). Although ApoE4 differs from its non-pathological ApoE3 isoform only by the C112R mutation, the molecular mechanism of its proteinopathy is unknown. METHODS: Here, we reveal the molecular mechanism of ApoE4 aggregation using a combination of experimental and computational techniques, including...
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