Article

Taurine Inhibits Apolipoprotein E4 Aggregation

2025-08-13

Abstract excerpt

Apolipoprotein E4 (ApoE4) is a major genetic risk factor in many neurodegenerative diseases, yet effective therapeutic strategies targeting its associated pathologies remain unresolved. The aggregation of ApoE4, a key pathological feature, can be attenuated by tramiprosate and its metabolite 3-sulfopropanoic acid. In this study, we investigated the potential of taurine, a close chemical analogue of tramiprosate, t...

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Literature Corpus work: 32375710-2456-53ee-bb4b-8b72aaf15069
DOI: 10.1101/2025.08.13.669519

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