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Article

Molecular Mechanisms of the R61T Mutation in Apolipoprotein E4: A Dynamic Rescue.

Biophysical journal - 21 Nov 2017

Williams Benfeard, Convertino Marino, Das Jhuma, Dokholyan Nikolay V

Abstract excerpt

The apolipoprotein E4 (ApoE4) gene is the strongest genetic risk factor for Alzheimer's disease (AD). With respect to the other common isoforms of this protein (ApoE2 and ApoE3), ApoE4 is characterized by lower stability that underlies the formation of a stable interaction between the protein's N- and C-terminal domains. AD-related cellular dysfunctions have been linked to this ApoE4 misfolded state. In this...

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Identifiers

PMID: 28916386
DOI: 10.1016/j.bpj.2017.08.026
PMCID: PMC5700245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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