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Article

Mechanically tuned 3 dimensional hydrogels support human mammary fibroblast growth and viability.

BMC cell biology - 16 Dec 2017

Woods Kathryn, Thigpen Catlyn, Wang Jennifer Peyling, Park Hana, Hielscher Abigail

Abstract excerpt

BACKGROUND: Carcinoma associated fibroblasts (CAFs or myofibroblasts) are activated fibroblasts which participate in breast tumor growth, angiogenesis, invasion, metastasis and therapy resistance. As such, recent efforts have been directed toward understanding the factors responsible for activation of the phenotype. In this study, we have investigated how changes in the mechanical stiffness of a 3D hydrogel alter...

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Identifiers

PMID: 29246104
DOI: 10.1186/s12860-017-0151-y
PMCID: PMC5732527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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