Article
A cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity.
Biomaterials - 1 Dec 2011
Liang Youyun, Jeong Jaehyun, DeVolder Ross J, Cha Chaenyung, Wang Fei, Tong Yen Wah, Kong Hyunjoon
Abstract excerpt
Three dimensional (3D) tumor spheroid models are becoming important biomedical tools for both fundamental and applied cancer studies, but current models do not account for different levels of cancer malignancy. Several studies have reported that the mechanical rigidity of a hydrogel plays a significant role in regulating the phenotypes of cancer cells adhered to the gel surface. This finding suggests that matrix...
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