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Gravitational forces and matrix stiffness modulate the invasiveness of breast cancer cells in bioprinted spheroids

4 Mar 2025

Abstract excerpt

The progression of breast cancer is influenced by the stiffness of the extracellular matrix (ECM), which becomes stiffer as cancer advances due to increased collagen IV and laminin secretion by cancer-associated fibroblasts. Intriguingly, breast cancer cells cultivated in two-dimensions exhibit a less aggressive behavior when exposed to weightlessness, or microgravity conditions. This study aims to elucidate the...

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PMID: 40124331
DOI: 10.1016/j.mtbio.2025.101640

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