Article
Desacetyl-α-melanocyte stimulating hormone and α-melanocyte stimulating hormone are required to regulate energy balance.
Molecular metabolism - 1 Mar 2018
Mountjoy Kathleen G, Caron Alexandre, Hubbard Kristina, Shome Avik, Grey Angus C, Sun Bo, Bould Sarah, Middleditch Martin, Pontré Beau, McGregor Ailsa, Harris Paul W R, Kowalczyk Renata, Brimble Margaret A, Botha Rikus, Tan Karen M L, Piper Sarah J, Buchanan Christina, Lee Syann, Coll Anthony P, Elmquist Joel K
Abstract excerpt
OBJECTIVE: Regulation of energy balance depends on pro-opiomelanocortin (POMC)-derived peptides and melanocortin-4 receptor (MC4R). Alpha-melanocyte stimulating hormone (α-MSH) is the predicted natural POMC-derived peptide that regulates energy balance. Desacetyl-α-MSH, the precursor for α-MSH, is present in brain and blood. Desacetyl-α-MSH is considered to be unimportant for regulating energy balance despite...
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