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Article

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin.

Nature medicine - 1 Sept 1999

Yaswen L, Diehl N, Brennan M B, Hochgeschwender U

Abstract excerpt

Pro-opiomelanocortin (POMC)-derived peptides (the melanocortins adrenocorticotropin, alpha-, beta- and gamma-melanocyte stimulating hormone; and the endogenous opioid beta-endorphin) have a diverse array of biological activities, including roles in pigmentation, adrenocortical function and regulation of energy stores, and in the immune system and the central and peripheral nervous systems. We show here that mice...

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Source

Identifiers

PMID: 10470087
DOI: 10.1038/12506

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin.PMID 10470087Read ↗

Pro-opiomelanocortin (POMC) Deficiency and Peripheral Melanocortins in ObesitySemantic proximity Read ↗

Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.Semantic proximity Read ↗

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36).Semantic proximity Read ↗

The melanocortin action is biased toward protection from weight loss in miceSemantic proximity Read ↗

[The central melanocortin system and its role in energy homeostasis].Semantic proximity Read ↗

The central melanocortin system and human obesity.Semantic proximity Read ↗

Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin.Semantic proximity Read ↗

Clinical review 127: Obesity as a neuroendocrine disease: lessons to be learned from proopiomelanocortin and melanocortin receptor mutations in mice and men.Semantic proximity Read ↗

Pro-opiomelanocortin and weight regulation: from mice to men.Semantic proximity Read ↗

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity.Semantic proximity Read ↗

The leptin melanocortin pathway and the control of body weight: lessons from human and murine geneticsSemantic proximity Read ↗

Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background.Semantic proximity Read ↗

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