Article
Hypothalamic proopiomelanocortin processing and the regulation of energy balance.
European journal of pharmacology - 11 Jun 2011
Wardlaw Sharon L
Abstract excerpt
Hypothalamic proopiomelanocortin (POMC) neurons play a key role in regulating energy balance and neuroendocrine function. Much attention has been focused on the regulation of POMC gene expression with less emphasis on regulated peptide processing. This is particularly important given the complexity of posttranslational POMC processing which is essential for the generation of biologically active MSH peptides....
Topics
- Animals
- Energy Metabolism
- Humans
- Hypothalamus
- Mutation
- Obesity
- Pro-Opiomelanocortin
