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Article

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans.

Nature genetics - 1 Jun 1998

Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A

Abstract excerpt

Sequential cleavage of the precursor protein pre-pro-opiomelanocortin (POMC) generates the melanocortin peptides adrenocorticotrophin (ACTH), melanocyte-stimulating hormones (MSH) alpha, beta and gamma as well as the opioid-receptor ligand beta-endorphin. While a few cases of isolated ACTH defici...

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Source

Identifiers

PMID: 9620771
DOI: 10.1038/509

Genes

POMC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9620771-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans.PMID 9620771Read ↗

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