Article
Desacetyl-α-MSH and α-MSH have sex specific interactions with diet to influence mouse gut morphology, metabolites and microbiota.
Scientific reports - 3 Nov 2020
Sun Bo, Vatanen Tommi, Jayasinghe Thilini N, McKenzie Elizabeth, Murphy Rinki, O'Sullivan Justin M
Abstract excerpt
The melanocortin peptides have an important role in regulating body weight and appetite. Mice that lack the desacetyl-α-MSH and α-MSH peptides (Pomctm1/tm1) develop obesity. This effect is exacerbated by a high fat diet (HFD). However, development of obesity in female Pomctm1/tm1 mice during chronic HFD conditions is not fully accounted for by the increased energy intake. We hypothesized that the protection...
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