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Article

Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients.

Cancer research - 1 Feb 2018

Hankey William, McIlhatton Michael A, Ebede Kenechi, Kennedy Brian, Hancioglu Baris, Zhang Jie, Brock Guy N, Huang Kun, Groden Joanna

Abstract excerpt

APC biallelic loss-of-function mutations are the most prevalent genetic changes in colorectal tumors, but it is unknown whether these mutations phenocopy gain-of-function mutations in the CTNNB1 gene encoding β-catenin that also activate canonical WNT signaling. Here we demonstrate that these two mutational mechanisms are not equivalent. Furthermore, we show how differences in gene expression produced by these...

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Source

Identifiers

PMID: 29212857
DOI: 10.1158/0008-5472.CAN-17-1357

Genes

APC
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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