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Article

Therapeutic targeting of the oncogenic Wnt signaling pathway for treating colorectal cancer and other colonic disorders.

Advanced drug delivery reviews - 1 Feb 2021

Caspi Michal, Wittenstein Amnon, Kazelnik Michal, Shor-Nareznoy Yarden, Rosin-Arbesfeld Rina

Abstract excerpt

The canonical Wnt pathway is one of the key cellular signaling cascades that regulates, via the transcriptional co-activator β-catenin, numerous embryogenic developmental processes, as well as tissue homeostasis. It is therefore not surprising that misregulation of the Wnt/β-catenin pathway has been implicated in carcinogenesis. Aberrant Wnt signaling has been reported in a variety of malignancies, and its role...

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PMID: 33346022
DOI: 10.1016/j.addr.2020.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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