Article
Mutational Analysis of Early, Low-Grade Bowel Polyps Defines a Subgroup with Concurrent, High-Risk Oncogenic Drivers Independent of Polyp Size.
Cancer research communications - 1 Aug 2025
Li Jun, Welham Zoe, Tse Benita, Gauci Chahaya, Ghazanfar Shila, Panwar Pratibha, Engel Alexander, Molloy Mark P
Abstract excerpt
The accumulation of pathogenic mutations in premalignant colorectal neoplasms is critical for colorectal cancer development; however, the frequency and diversity of pathogenic driver mutations in early-stage colorectal polyps is incompletely known. We investigated this by whole-exome sequencing of low-grade dysplasia (LGD) colorectal polyps and paired germline DNA. Interestingly, in these early lesions, there was...
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