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Article

Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.

Molecular cancer research : MCR - 1 Dec 2016

Hesson Luke B, Ng Benedict, Zarzour Peter, Srivastava Sameer, Kwok Chau-To, Packham Deborah, Nunez Andrea C, Beck Dominik, Ryan Regina, Dower Ashraf, Ford Caroline E, Pimanda John E, Sloane Mathew A, Hawkins Nicholas J, Bourke Michael J, Wong Jason W H, Ward Robyn L

Abstract excerpt

Laterally spreading tumors (LST) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer, depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and colorectal cancers offers an opportunity to delineate key molecular alterations that drive malignant transformation in the colorectum. In a discovery cohort of 11 LSTs and paired...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27671336
DOI: 10.1158/1541-7786.MCR-16-0175

Genes

ANK2
ANO5
NRXN1
RGMB
SLITRK1
SLITRK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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