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Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms

20 Aug 2015

Abstract excerpt

The evolutionarily conserved Wnt signaling pathway plays essential roles during embryonic development and tissue homeostasis. Notably, comprehensive genetic studies in Drosophila and mice in the past decades have demonstrated the crucial role of Wnt signaling in intestinal stem cell maintenance by regulating proliferation, differentiation, and cell-fate decisions. Wnt signaling has also been implicated in a...

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Share to Cancer-related gene regulation
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 26289750
DOI: 10.1152/ajpcell.00117.2015

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